Chemotherapy and radiotherapy are ruthless attacks to the body. A number of food sources, supplements and lifestyle can improve quality of live, improve your immune system.
A great number of food sources are scientifically investigated and are causing cell death of cancer cells, work in synergy with drugs, making them more effective and can reduce build up resistance of cancer cells against cytostatic drugs, target drugs and radiotherapy.
More and more it's getting clear that FOOD and LIFESTYLE are the major causes of cancer. So stay away from bad food sources and bad habits listed in the DON'T DO list. Realize that many cytostatic drugs and radiotherapy are cancerous themselves. Reason to drastically change bad habits and carefully study what's best to eat and to do. It doesn't mean that you have chew carrots the whole day. There many pleasant drinks and foods that you can take.
This list can be useful, on almost all subjects, as a cancer preventive list
This list is supported ONLY by scientific research and publications
This scientific research is hardly known or no time is taken to inform patients beside the medical treatment.
Almost unnecessary to mention but organic, pesticides free produced foods are strongly recommended.
This list will never be complete. So every valuable research/publication is welcome.
This website has no commercial interests in any of the products, however some are unique and mentioned by trade name. Any similar products will be listed.
FLAXSEED, FLAXSEED OIL, OMEGA 3
TURMERIC in combination with BLACK PEPPER/GRAPFRUIT and GREEN TEA
MUSHROOMS in combination with RBAC (Daiwa Japan),IMMUTOL (Biotec SA Norway)
RED WINE, BLUE GRAPES(juice)
OLIVE OIL, OLIVES, OLIVE LEAVE EXTRACT
REDCURRENT BERRIES, SEA-BUCKTHORN BERRIES
MILK THISTLE EXTRACT, SILYMARINE
APPLE PEELINGS and APPLE JUICE
All chapters in bleu are not ready yet but research is available.
HIGH NITRATE FOOD:NITROSAMINES
PRODUCTS based on LINOLEIC ACID
ALFALFA, MUNG BEAN SPROUTS
I DO FOOD
FLAXSEED, FLAXSEED OIL , OMEGA 3
Flaxseed of the Flaxplant contains Omega 3,6,7,9 oils and very high levels of Lignans. The Lignans are located in the hard peel and not in the oil. The Lignans show a strong anti-cancer function, particularly for breast and prostate cancer.
The peel however contains small amounts of Hydrogen Cyanide precursors (Linustatin). If used regularly, this peel can make you sick. By cooking the seed, the Hydrogen Cyanide precursors will disappear, however also the useful substances. Consuming more than 20 gram per day, it's also better to take extra minerals, Zinc, Calcium, Selenium and (Iron, only when red bloodcell counts are low) to compensate the loss caused by Phytic acid that are common in whole grains. Vitamin B6 to compensate for the loss caused by Linatine in flaxseed
Golden flaxseed (Linola) has the lowest values of Linostatin and and by far the highest values of Lignans compared to the brown colored flaxseed and can be used without cooking.
Omega 3 levels in Linola seeds are very low (only 2%). So for Omega 3 you need to use the flaxseed oil from brown flaxseed that contains around 60% Omega 3.
The whole seed is very resistant and will not be digested. So it needs to be ground in a coffee grinder or you can make a shake in a blender. Linola costs around $7,- per kilo, 10-25 gram per day. Ground Flaxseed is only 2-3 hours fresh and will oxidize quickly. Organic Flaxseed oil can be bought in many organic stores. Flaxseed-oil does oxidize slowly and needs to be stored in the fridge.
Most important substances:
OMEGA 3 OILS (ALA)
The Linola flaxseed peel contains by far the highest concentration Lignans. 2-3X that of brown flaxseed and 200-300X more then the next in line, Oat. Lignans are converted by bacteria in the stomach into 2 Phyto Estrogens: Enterodiol en Enterolactone. Hypotheses is that these weak Phyto-Estrogens blocks the function of the strong natural Estrogens. http://www.ncbi.nlm.nih.gov/pubmed/11445478
It's also stops tumor growth through another mechanism, other than blocking the natural estrogen
Many trials are done, partly with good results but also without results but in no case negative results of the Phyto-Estrogens. This in contrary of the Phyto-Estrogens in Soy. In this link of Oregonstate (Linus Pauling institute) you can find more than 25 publications on Lignans. http://lpi.oregonstate.edu/infocenter/phytochemicals/lignans/
Function of Omega 3, (ALA or Alfa Linolenic Acid) in Flaxseed:
Flaxseed oil of a common bread of brown flaxseed contains the following substances:
Alpha Linolenic acid >60% Omega 3 ALA
Linoleic acid 10-16% Omega 6 GLA, LA
Palmitic acid 5% Omega 7
Oil acid 10-20% Omega 9 OA
Stearic acid <10%
Erucic acid <1%
ALA suppresses strongly the P185Her-2/Neu oncoprotein and the activity of the Luciferase reporter gene of the Her 2 promoter. Also a strong synergy was found, increased cytotoxic activity, between Herceptin and ALA in flaxseed. http://www.ncbi.nlm.nih.gov/pubmed/17134970
In the following scientific investigating a strong synergy is measured between the chemo sensitivity of Taxol and GLA and ALA. LA , Omega 6 shows no synergy.
Very concerning are the following investigations where Linoleic acid, Omega 6, LA (Sunflower- Soy- and Corn oil) supports cancer growth strongly in vitro, specially breast cancer Her2Neu expression.
(Gamma Linoleic Acid, GLA and Conjugated Linoleic acid, CLA are strongly suppressing Her2Neu.)
In vivo trials on rats confirmed the in vitro research. Rats feed with Corn oil with high Concentration Omega 6 showed significant higher incidence of cancer compared to rats feed with Olive oil, OA, Omega 9. http://www.ncbi.nlm.nih.gov/pubmed/12883717?dopt=Abstract
Omega 6 however is an essential acid oil. How can Omega 6 be cancerous?
Following can explain how Omega 3 has an important role in the metabolism of
Omega 6 to the "good" Prostaglandins series 1 (PGE1) or the "bad" Prostaglandins series 2 (PGE2)
Also the metabolism of Omega 3 to the "good" Prostaglandins series 3 (PGE3). Good and bad is not in place because in balance all PGE 1, 2, and 3 have a function.
A shortage on Omega 3 will cause the Omega 6 to follow a pathway to the Prostaglandins
series 2. This because the Delta 5 enzyme has a privilege to convert Omega 3. Not enough Omega 3 and the Delta 5 enzyme will make Arachidonic acid (AA) of the Omega 6.
Together with the COX2 enzyme it will make a group of substances called Prostaglandins series 2 (PGE2) that causes inflammation reactions, swelling of lymph nodes, and swelling of damaged tissue. Permanent chronic infections are a feeding ground for cancer.
AA, COX2, PGE2 are connected to many cancers working together with a protein Factor NF-kB. The PGE2 function is to repair damaged and inflammated tissue, enabling the growth of new blood vessels (angio-genesis).
Cancerous cells forming tumors are also strongly stimulated by these PGE2. Cancerous cells typically stimulate the formation of the protein Factor NF-kB that will stimulate the enzyme COX2 that will boost the progression of cancer.
Enough Omega 3 and the Omega 6 will follow a pathway to the Prostaglandins series 1 (PGE1) that will improve the function of the white blood cells and the maturation of the group of special NK cells, the iNKT cells (T Killer Cells). Omega 3 will follow the pathway to Prostaglandins series 3 (PGE3) who are suppressing inflammation.
Following link clarifies the metabolism pathways of Omega 3 and 6
The Delta 5 and 6 enzyme needs for a good function enough vitamin B3 (Niacin), B6, C, Zinc and Magnesium.
Research shows that high expression of COX2 the last step in the metabolism pathway to the PGE2, promotes strongly Colorectal cancer. High levels of COX2 are related to bad prognoses.
Another link between developing a tumor, COX2 and PGE2 can be infectious spots in the artery causing Thrombosis
Next a strong link between thrombosis, micro-particles and developing tumor in a major research program of the University of Leiden,The Netherlands. So even death cancer cell can still continue trigger other cell by its leftovers , micro-particles
Drugs for blocking COX2 are numerous but with many side effects also blocking PGE1 and PGE3
Aspirin, Apple peelings, Resversatol (red wine) Red Current Berries show to be the most effective natural COX2 enzyme inhibitor.
But with enough Omega 3 you can prevent building up the metabolite AA Arachidonic acid that will form PGE2 with help of the COX2 enzyme.
LINOLEIC ACID or OMEGA 6, A UNSATURATED OIL IS WIDELY INVESTIGATED AS GOOD FOR HEART AND ARTERY. BUT LIKE A PACKAGE OF SIGARETTES IT SHOULD GET A LABEL, OMEGA 6 IS CANCEROUS.
Don’t use Sunflower-oil, Soy-oil or Corn-oil or other Linoleic-Oil or Omega 6 products.
This is difficult because it’s in almost all processed food products. In our "western" diet we consume 15 x to 25 x more Omega 6 compared to Omega 3. Even Olive-oil based products contains more Sunflower-oil than Olive-oil.
Fry and bake in Palm-oil or Olive-oil. Use Flaxseed-oil Omega 3 for salads. Fish-oil contains also Omega 3 but the quality is in doubt because of high amounts of toxic heavy metals, PCB and Dioxine contamination.
Flaxseed-oil and/or Omega 3 is not suitable for baking and frying. All Omega 3 and 6 oils will form 4-HNE that is commonly excepted, carcinogen.
FRYING AND BAKING IN SUNFLOWER OR CORN OIL IS 3X BAD. IN SOY OIL 4X BAD
1 Too much Omega 6 will give Arachidonic acid, COX2- PGE2, strongly promoting tumor growth
2 Heating unsaturated oils will form 4-HNE (carcinogen) that will absorbed in the fried food.
3 Heating food over 250 F will form Acryl-amide, a substance that's considered to be cancerous (See FDA List)
4 Soy(oils) contains 3 Phyto estrogens that are a double edge sword (see chapter: Don't Do Soy)
List of Acrylamide containing food and drinks, investigated by the FDA (USA Food and Drug Administration)
Together, the anti-cancerous function of Lignans, the positive effect of Flaxseed-oil for heart and artery, the anti cancerous pathways of Omega 3 and the synergy with cancer drugs, Flaxseed Lignans and Flaxseed oil can be considered to be therapeutic.
Red current berries, one of the best COX2 inhibitors
After millions of years, Broccoli has developed a defense system against diseases that show the same cell growth as the growth of cancer cells. Mike D Biologist at cancer research UC Berkely investigated Broccoli for more then 10 years.
Heat up Broccoli(sprouts) in water between 60C-80C (140-180F) around 10 minutes.
Too high temperature and the Myrosinase enzyme will not work.
Too Low temperature and the Epithiospecifier proteine (ESP) in broccoli binds to the Sulforaphane to form Sulforaphanenitrile, NOT ACTIVE. This protein ESP disappears after heating the Broccoli over 60C (140F).
Don’t boil ! You can cook tea from the young Broccoli sprouts. The sprouts contains 20-50x the amounts of Glucosinolates which converts to Sulforaphane. To much work. A supplement called ActivaMune can be an alternative http://www.activamune.com This supplement contains Sulforaphane and DIM.
Most important Substances:
DIM or 3,3'-diindolylmethane (from the Indole-3-carbinol)
By heating the Broccoli the Myrosinase enzyme will be released reacting with Glacupharin to Sulforaphane. Sulforaphane promotes apoptosis but also triggers messenger substances to activate the immune system.
It promotes de function of the Nuclear Factor-Erythroid 2 P45-related factor 2 or Nrf2 that regulates many anti-oxidation and cell renewal processes. Whereby the Glutathione S Transferase.
Relation between Nrf2 en DNA regulatory element, the Antioxidant Response Element, ARE.
Relation between Nrf2 and KEAP1 gene.
Function DIM 3,3'-Diindolylmethane (Indole-3-carbinol).
Another substance in Broccoli is Indole-3-carbinol that needs to be transformed into DIM. Supplements based on I3C (Indole-3-carbinol) are useless and even dangerous in high doses.
THE CONVERSION TO DIM, THE ACTIVE SUBSTANCE, HAS TO TAKE PLACE UNDER MILD ACID CONDITIONS.
SO, SQUEEZE A LEMON OR ADD A SPOON OF VINEGAR IN THE WARM WATER DURING HEATING OF THE BROCCOLI, BRUSSEL SPROUTS, FLOWE CABBAGE AND GREEN CABBAGE.
DIM reveals the cancer cell that tries to hide as a normal cell The most exciting aspect of DIM's activity is that it modulates Interferon-Gamma sensitivity by increasing the formation of its receptors on cell surfaces.
What this means is that DIM forces the cells that are cancerous to not hide their status as cancer cells from the immune system as effectively as they normally would, enabling the immune system to recognize them as un-normal cells and attack and kill them.
Here an interesting investigating that concludes strong synergy between TAXOL and DIM.
TAXOL is one of the most used chemotherapy drugs that also originated from nature. The bark of the Pacific Yew Tree, a species of the Taxes. Drugs resistance is well known feature of Taxol and researchers think that the synergy of DIM is based on preventing drugs resistivity.
Broccoli, Brussels Sprouts, Flower cabbage, Green Cabbage contains the same substances.
3 CURCUMA in combination with BLACK PEPPER, GRAPEFRUIT and GREE TEA
Curcuma or Koenjit is the most important part of yellow curry. It's made of the root of the Turmeric plant, a Ginger species. It's origin is Malaysia but it is now widely spread in India. There are many species of the Turmeric plant but the Turmeric Longa contains most of the curcuma substances. It's used for wound healing but in recent years it shows a remarkable strong anti-cancer activity. The main substance Curcuma contains around 4-7 % Curcumin.
Most imporant substances: Diferuloylmethanes
The fast metabolism of Curcumin results in a low availability in the bloodstream. However research shows that momentary high levels of Curcumin as well as prolonged times of lower levels are effective and will influence almost all tumor biomarkers.
Curcumin suppresses the EGFR activity that supports tumor growth. EFGR is an cell membrane receptor. If mutated it shows an over expression and can cause an avalanche of signaling substances. Erb2 or Her2/Neu for example. http://carcin.oxfordjournals.org/cgi/content/abstract/bgi272v1
Curcumin and prostate cancer, breast cancer. The synergy with Gemcitabine and the sensitation of cancer cells to radiotherapy. http://cancerres.aacrjournals.org/cgi/content/full/67/5/1988
The presence of curcumin in blood is restricted by the metabolism processes. Research is ongoing to make artificial curcumin that supply 30x the amount of the biological active substances in de blood. This however will be a medicine.
Another way to improve Curcumin blood plasma levels is to mix Turmeric with black pepper. Tests show a 20-50 x higher availability of Curcumin in the blood. http://www.ncbi.nlm.nih.gov/pubmed/9619120
Peperine is a component of BLACK PEPPER and blocks typical metabolism (P450) enzymes P-glycoprotein and CYP3A4. Curcumin will stay longer in the blood and higher concentrated. http://www.ncbi.nlm.nih.gov/pubmed/12130727
Peperine is also known to block bad substances/chemicals, also chemotherapeutic drugs. So be careful with black pepper.
The substances Bergamottin and Paradisin A of GRAPEFRUIT(JUICE) shows the same suppressing of CYP3A4 enzym and P-Glycoprotein. An alternative for peperine.
Curcumin is used in private clinics in Swiss as part of alternative therapy. Between 3-7 gram Curcumin per day. For this you need to take supplements. Curcuma contains only 4-7% Curcumin. Supplements are concentrated up to 95% Curcumin.
So combine CURCUMIN Supplements with BLACK PEPPER, GRAPEFRUIT(JUICE) and GREEN TEA.
4 MUSHROOMS AND VITAMIN C
Mushrooms belong to the species of Fungi. In contrary to plants, mushrooms don't get their energy from sunlight but from dead organism like wood and leaves. The enzymes in the mushrooms are able to break down the tough fibers (Polysaccharide) of all sort of plants into unique substances.
Our body is not able to digest whole fibers. However the broken fibers by the mushroom enzymes are well digested and have a special anti-cancer activity by boosting the immune system.
In combination with vitamin C, it causes direct cancer cell death by apoptosis.
Some Mushrooms are very toxic by irreversible destroying the liver. The edible mushroom are the White Button, Cantharel, Oyster, Which's Butter. Exotic species are getting more popular like the Shii-take , Mai-take, Agaricus Blazei Murill, Krestin or PSK
Most important substances:
BETA 1,3-D GLUCAN
BETA 1,6-D GLUCAN
Polysaccharo Peptides Proteoglycans or Beta-D-Glucan-proteins
Conjugated linoleic acid (CLA) Rumenic acid
Function of the Beta Glucans
Immune Modulation: It is proven that the Glucan and Polysaccharo-peptides are functioning as immune modulators. They have the capability to strengthen the immune system. This by multiplying the amount the amount of NK (natural Killer ) cells.
Furthermore investigations show an improved function of the Macrophages, Monocytes, Neutrofiles and Dendritic cells.
Also the function of important messenger substances are improved like Interleukine, Interferon and the Colony Stimulating Factors or Glycans who are binding to stem cells and promote cell dividing and differentiation of the white blood cells.
Lymphocytes, that are regulating the production of Beta cells and T cells are also stimulated.
Synergy between the Shii-take and 5-FU by increasing chemo sensitivity vs.Colon cancer. http://www.mupnet.com/JOCM%203(1)%2015-22.pdf
The anti-aromatase function of Rumenic acid (CLA) in Mushrooms. CLA is a natural trans fat that's also found in eggs, cheese, milk and red meat of typical grass eaters like cows. In contrary to Linoleic acid, CLA shows a clear anti-cancer function. http://www.ncbi.nlm.nih.gov/pubmed/17178902 http://en.wikipedia.org/wiki/Aromatase
Research of CLA by investigating of 400 women in Finland shows a 2,5x lower incidence on breast cancer of women with relative high CLA blood levels. http://www.informaworld.com/smpp/content~content=a785829808~db=all
Direct cytotoxic function of the substances in the Which's Butter mushroom and lung cancer cells 549. This by phagocytosis en apoptosi. Research of 2008. http://www.jstage.jst.go.jp/article/bbb/72/5/1283/_pdf
Following scientific investigation shows a strong cytotoxic function of mushroom extracts, Arabinoxylan and Vitamin C. The supplements alone show a low citotoxic function and are just a bit effective at almost impossible quantities. Vitamin C also has no record being cytotoxic. It's even under doubt causing free radicals reaction with Iron.
The combination of the supplements with vitamin C gives a strong citotoxic function at low blood plasma levels in trials with bladder cancer cell lines. It's likely that the same mechanism will work on other cancer cell lines. Further investigations with this promising combination is urgently needed. http://www.thorne.com/media/Bladder12-1.pdf
5 RED WINE, BLUE GRAPE(JUICE)
Red wine made of the blue grape has recently been investigated to have a strong anti-cancer function through different mechanisms. It's already known for several years that red wine has an anti-cancer function.
Recent research however shows that red wine is even more powerful than ever expected. The Phyto-estrogens in the blue grape peel have a strong preventive function.
Most important substances:
RESVERATROL or 3,5,4'-trihydroxy-trans-stilbene
Quercetine and Tannine
1st function is slowing down, blocking cell growth by suppressing MAPK fosforylisation. To explain, it looks like switching on/off of an enzyme or cell wall receptor that is used to let cells communicate with each other. Most of time to promote cell dividing.http://en.wikipedia.org/wiki/MAPK/ERK_pathway http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/819.4
2nd function is though anti-aromatase of the Phyto-estrogen, Resveratrol. 3rd function through cell death by apoptosis. 4th function is through anti-Angiogenesis (formation of blood vessels in tumor).
Next an investigation that confirms apoptosis and angiogenesis in almost ALL breast cancer cell lines. http://www.ncbi.nlm.nih.gov/pubmed/16356836
6 WATERCRESS AND GARDENCRESS
White Watercress is one the 6 species of the watercress that is cultivated and sold mainly for salads and as garnishing. Also Watercress soup is an old Dutch recipe from Limburg, a somewhat obsolescence recipe. Watercress and Gardencress have a light sharp spicy taste similar to radish.
Most important substances: Isothiocyanates
Watercress, Phenethyl-Isothiocyanate of PEITC
Gardencress, Benzyl Isothiocyanate of BITC
Function of PEITC and BITC.
Neutralizing of precursors of carcinogen substances from, for example cigarette smoke.
Some precursors of carcinogen needs an enzyme to convert to a carcinogen. Examples are the Cytochrome P450 enzymes. They are called P450 because of the typical absorption of light with a wavelength of 450 nm.
By the P450 enzymes, the formed carcinogens are able to bind to DNA and cause the mutations.
This investigation shows how PEITC effectively blocks the oxidative metabolism of the lung cancer causing substance NNK from cigarette smoke.
BITC and the apoptosis mechanism of breast cancer cell lines.
BITC and an in vitro investigation of ovary cancer cell lines.
BITC and the apoptosis mechanism in pancreas cancer cell lines, already effective at very low concentration in the blood. Values that are easy to realize by eating Gardencress.
7 OLIVE OIL, OLIVE, OLIVELEAF EXTRACT
Goddess Athena en God of the sea Poseidon had a quarrel and claimed a piece of land. Zeus would judge and who came up with the best invention would win. Athena came with the Olive tree and won.
The Nr 2 was not mentioned, maybe marine sponges?
Choose “extra vierge”, First cold pressing of organic farmed Olive trees. Use for frying, baking and salads.
Most important Substances: Triterpenes
MASLIMIC ACID MA
Quercetins: see Lovage
Function olive oil
Olive-oil, Oil acid, breast cancer Her2/Neu3+
The skin of the Olive, Maslimic acid, colon cancer
ONE OF THE MOST IMPORTANT SUBSTANCES ARE FOUND IN THE LEAVES OF THE OLIVE TREE.
Be careful that you buy the extract of FRESH leaves. In contrary to some opinions it's tasting good.
Most important substances:
OLEUROPEIN and it's metabolite HYDROXY TYROSOL
Oleuropein and blocking the invasive behavior of cancerous cells.
Oleuropein and breast cancer with Her2/Neu over expression, synergy with Herceptin. Lifting up resistance of the target drug Herceptin.
Hydroxy tyrosol and Leukemia and colon cancer cell lines.
Hydroxy tyrosol and it's suppression of pro-inflammatory genes that are linked to many cancers.
Apigenin-7-Glucoside and leukemia HL60 cell line.
Furthermore Oleuropein is the only identified component that is proven to extend cell life. It's life elixir capabilities needs still to be proven.